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2022\u5e748\u67086\u65e5\u81f39\u65e5\u4e3e\u529e\u7684\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a\uff08IASLC\uff09\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u5df2\u843d\u4e0b\u5e37\u5e55\u3002\u5728\u4eca\u5e74WCLC\u5927\u4f1a\u4e0a\uff0c\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u5c0f\u5206\u5b50KRAS G12C\u6291\u5236\u5242D-1553\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u5165\u9009\u672c\u6b21\u5927\u4f1a\uff0c\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u4e0a\u6d77\u5e02\u80f8\u79d1\u533b\u9662\u7684\u9646\u821c\u6559\u6388\u5728\u672c\u6b21\u5927\u4f1a\u4e0a\u5c31D-1553\u76841\u671f\u4e34\u5e8a\u6570\u636e\u4f5c\u53e3\u5934\u62a5\u544a\uff0c\u5206\u4eab\u4e86\u4ee4\u4eba\u632f\u594b\u7684\u6570\u636e\u7ed3\u679c\u3002<\/p>
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\u5728600 mg BID\u7ec4\u768462\u4f8b\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\uff0c23\u4f8bPR\uff0c33\u4f8bSD\uff0cORR\u4e3a37.1%\uff0823\/62\uff09\uff0cDCR\u4e3a90.3%\uff0856\/62\uff09\uff1b\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a6.2 [1.6\uff0c9.9]\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e3a6.8 [4.1\uff0cNA]\u4e2a\u6708\uff08\u6570\u636e\u5c1a\u4e0d\u6210\u719f\uff09\uff0c\u4e2d\u4f4dDOR\u4e3a5.4 [4.1\uff0cNA]\u4e2a\u6708\u3002\u572823\u4f8b\u75be\u75c5\u7f13\u89e3\u7684\u60a3\u8005\u4e2d\uff0c\u670919\u4f8b\u4ecd\u5904\u4e8e\u7f13\u89e3\u72b6\u6001\u300236\u4f8b\uff0858.1%\uff09\u60a3\u8005\u4ecd\u5728\u6301\u7eed\u6cbb\u7597\u4e2d\u300226\u4f8b\u60a3\u8005\u7ec8\u6b62\u6cbb\u7597\uff0c\u5927\u90e8\u5206\u7531\u4e8e\u75be\u75c5\u8fdb\u5c55\u800c\u7ec8\u6b62\u3002<\/p>
D-1553\u5728\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u4e2d\u7684\u7597\u6548\u4ea6\u632f\u594b\u4eba\u5fc3\uff0cDCR\u9ad8\u8fbe100%\uff01\u57283\u4f8b\u9885\u5185\u6709\u9776\u75c5\u7076\u7684\u60a3\u8005\u4e2d\uff0c1\u4f8b\u8111\u90e8\u75c5\u7076PR\uff0c2\u4f8b\u8111\u90e8\u75c5\u7076SD\uff0cORR\u4e3a33%\uff0cDCR\u4e3a100%\u3002\u57283\u4f8b\u9885\u5185\u4ec5\u6709\u975e\u9776\u75c5\u7076\u7684\u60a3\u8005\u4e2d\uff0c3\u4f8bSD\uff0cDCR\u4e3a100%\u3002<\/p>
D-1553\u5728\u665a\u671f\u548c\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\uff0cORR\u8fbe37.8%\uff0cDCR\u8fbe91.9%\u3002\u53e6\u5916\uff0cD-1553\u5728\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u4e2d\u5177\u6709\u4e00\u5b9a\u7684\u7597\u6548\u3002\u4ece\u5b89\u5168\u6027\u65b9\u9762\u6765\u770b\uff0c<\/strong>\u4ece600 mg\/\u5929\u81f31200 mg\/\u5929\u5242\u91cf\u8303\u56f4\u5185\uff0c\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff1b<\/strong>\u901a\u8fc7\u4e2d\u65ad\u7ed9\u836f\u6216\u964d\u4f4e\u5242\u91cf\uff0c\u5927\u591a\u65703\u7ea7\u62164\u7ea7\u7684\u809d\u529f\u80fd\u5f02\u5e38\u548c\u80c3\u80a0\u9053\u53cd\u5e94\u53ef\u63a7\u53ef\u7ba1\u7406\uff0c\u7ee7\u7eed\u6cbb\u7597\u540e\u8010\u53d7\u6027\u826f\u597d\u3002<\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":" 2022\u5e748\u67086\u65e5\u81f39\u65e5\u4e3e\u529e\u7684\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a\uff08IASLC\uff09\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u5df2\u843d\u4e0b\u5e37\u5e55\u3002\u5728\u4eca\u5e74WCLC…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-5741","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/posts\/5741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/comments?post=5741"}],"version-history":[{"count":5,"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/posts\/5741\/revisions"}],"predecessor-version":[{"id":5750,"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/posts\/5741\/revisions\/5750"}],"wp:attachment":[{"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/media?parent=5741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/categories?post=5741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jfyapnf.cn\/wp-json\/wp\/v2\/tags?post=5741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}